Has your company ever perform peptide-hapten conjugations for regulatory studies? Is there any method to analyze the peptide-hapten stability? This is important since if there is not a positive response after the immunization we should know whether the conjugation was stable or not. Is there any method to determine the amount of peptide that is conjugated to the hapten? Does your company provide a Quality Control (QC) for the conjugation procedure?

Several clients have had TriLink link small molecules, peptides, and oligonucleotides to KLH using TriLink’s bioconjugation technology, and in all cases, have isolated antibodies. Yes, the linkage between the peptide and the KLH is chromophoric and can be quantified spectrophotometrically. We can provide whatever data you need, including protein concentration and number of peptides/KLH.