Dear Ben,

At the smaller scales, 15 umole and below, there is no guarantee of final yield. Each oligo has unique synthetic properties based on its sequence and modifications; therefore it is not easy to predict how much material will result from a particular synthesis.

Our general expectations for HPLC purified unmodified DNA oligonucleotides are as follows:

0.2 µmole scale 5 – 15 OD260 units (˜0.15 – 0.5 mg)
1.0 µmole scale 20 – 60 OD260 units (˜0.66 – 2 mg)

If you require a specific yield, please let us know when you place your order or request a quote.

Regards,

Danica