TriLink’s random sites are optimized to produce as close to a 1:1:1:1, A:C:G:T base ratio in the resulting wobble site as possible. TriLink has done extensive research in the area of randomer oligonucleotides. In aptamers any bias can cause misrepresentation of the sequence space, which can limit the search for aptamers that bind the desired target with high specificity. The randomness of TriLink’s library manufacturing process was confirmed by NeoVentures and featured in the whitepaper Validation of Random Library for Aptamer Selection.