The answer depends on many factors, beginning with how easy it is to prepare your particular compound. In general, we are willing to consider quoting on kilogram or multi-kilogram quantities of straightforward phosphoramidites, such as our linkers. We are able to prepare modified nucleotides in 10 grams or more per single synthetic prep if the purification is not problematic. Before we consider a large scale synthesis, we will try it on a much smaller scale first. We can also prepare multiple smaller synthetic batches (this reduces risk to both parties) that can be recombined prior to analysis to prepare single large lots. Please contact us to discuss your particular project.